Azari, N., Rezaee, M., Dayer, D., & Tabandeh, M. R. (2024). Dimethyl itaconate modulates neuroprotective effect on primary rat astrocytes under inflammatory condition by regulating the expression of neurotrophic factors and TrkA/B-P75 receptors. Neurological Research, 46(12), 1137–1148.
Bedoschi, G., Navarro, P. A., & Oktay, K. (2016). Chemotherapy-induced damage to ovary: Mechanisms and clinical impact. Future Oncology, 12(20), 2333–2344.
Ben-Aharon, I., Bar-Joseph, H., Tzarfaty, G., Kuchinsky, L., Rizel, S., Stemmer, S. M., & Shalgi, R. (2010). Doxorubicin-induced ovarian toxicity. Reproductive Biology and Endocrinology, 8, 1–7.
Cai, G., Si, M., Li, X., Zou, H., Gu, J., Yuan, Y., ... & Bian, J. (2019). Zearalenone induces apoptosis of rat Sertoli cells through Fas‐Fas ligand and mitochondrial pathway. Environmental Toxicology, 34(4), 424–433.
Chauvin, S., Cohen-Tannoudji, J., & Guigon, C. J. (2022). Estradiol signaling at the heart of folliculogenesis: Its potential deregulation in human ovarian pathologies. International Journal of Molecular Sciences, 23(1), 512.
Daneshmandi, S., Choi, J. E., Yan, Q., MacDonald, C. R., Pandey, M., Goruganthu, M., ... & Mohammadpour, H. (2024). Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies. Nature Communications, 15(1), 2803.
Ferreira, A. V., Kostidis, S., Groh, L. A., Koeken, V. A., Bruno, M., Baydemir, I., ... & Netea, M. G. (2023). Dimethyl itaconate induces long-term innate immune responses and confers protection against infection. Cell Reports, 42(6), Article 112558.
Gao, Y., Wu, T., Tang, X., Wen, J., Zhang, Y., Zhang, J., & Wang, S. (2023). Increased cellular senescence in doxorubicin-induced murine ovarian injury: Effect of senolytics. Geroscience, 45(3), 1775–1790.
Guo, S., Quan, S., & Zou, S. (2021). Roles of the notch signaling pathway in ovarian functioning. Reproductive Sciences, 28(10), 2770–2778.
Guo, Y., Xue, L., Tang, W., Xiong, J., Chen, D., Dai, Y., ... & Wang, S. (2024). Ovarian microenvironment: Challenges and opportunities in protecting against chemotherapy-associated ovarian damage. Human Reproduction Update, 30(5), 614–647.
He, F., Wang, F., Yang, Y., Yuan, Z., Sun, C., Zou, H., ... & Han, T. L. (2023). The effect of growth hormone on the metabolome of follicular fluid in patients with diminished ovarian reserve. Reproductive Biology and Endocrinology, 21(1), 21.
Hetzler, K. L., Hardee, J. P., LaVoie, H. A., Murphy, E. A., & Carson, J. A. (2017). Ovarian function’s role during cancer cachexia progression in the female mouse. American Journal of Physiology-Endocrinology and Metabolism, 312(5), E447–E459.
Hosseinkhani, F., Hosseinifar, S., & Tabandeh, M. R. (2024). Dimethyl itaconate mitigates histological distortions, inflammation, and oxidative stress in the rat model of polycystic ovary syndrome. The Journal of Steroid Biochemistry and Molecular Biology, 243, Article 106546.
Khadem, M. D., Tabandeh, M. R., Haschemi, A., Kheirollah, A., & Shahriari, A. (2022). Dimethyl itaconate reprograms neurotoxic to neuroprotective primary astrocytes through the regulation of NLRP3 inflammasome and NRF2/HO-1 pathways. Molecular and Cellular Neuroscience, 122, Article 103758.
Laftah, A. H., Alhelfi, N., Al Salait, S. K., Altemimi, A. B., Tabandeh, M. R., Tsakali, E., ... & Abedelmaksoud, T. G. (2025). Mitigation of doxorubicin-induced liver toxicity in mice breast cancer model by green tea and Moringa oleifera combination: Targeting apoptosis, inflammation, and oxidative stress. Journal of Functional Foods, 124, Article 106626.
Markowska, A., Antoszczak, M., Markowska, J., & Huczyński, A. (2024). Gynotoxic effects of chemotherapy and potential protective mechanisms. Cancers, 16(12), 2288.
Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., ... & O’Neill, L. A. (2018). Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 556(7699), 113–117.
Nguyen, N. M. P., Chang, E. M., Chauvin, M., Sicher, N., Kashiwagi, A., Nagykery, N., ... & Oktay, K. (2025). AMH protects the ovary from doxorubicin by regulating cell fate and the response to DNA damage. Proceedings of the National Academy of Sciences, 122(5), e2414734122.
Nishi, K., Gunasekaran, V. P., Arunachalam, J., & Ganeshan, M. (2018). Doxorubicin-induced female reproductive toxicity: An assessment of ovarian follicular apoptosis, cyclicity and reproductive tissue histology in Wistar rats. Drug and Chemical Toxicology, 41(1), 72–81.
Ojo, O. A., Nwafor-Ezeh, P. I., Rotimi, D. E., Iyobhebhe, M., Ogunlakin, A. D., & Ojo, A. B. (2023). Apoptosis, inflammation, and oxidative stress in infertility: A mini review. Toxicology Reports, 10, 448–462.
O’Neill, L. A., & Artyomov, M. N. (2019). Itaconate: The poster child of metabolic reprogramming in macrophage function. Nature Reviews Immunology, 19(5), 273–281.
Rad, P., Safari, F., Mohammadi, J., & Delaviz, H. (2021). Preserved ovarian function following toxicity with doxorubicin in rats: Protective effect of nasturtium officinale extract. Iranian Journal of Toxicology, 15(1), 57–64.
Ramezani-Aliakbari, K., Jalali, S. A., Alinejad, M., Jeddi-Tehrani, M., & Shabani, M. (2024). 5-Fluorouracil effectively depletes tumor induced myeloid derived suppressor cells in 4T1 mammary carcinoma model. Avicenna Journal of Medical Biotechnology, 16(4), 244–250.
Saleh, D., Abdelbaset, M., Hassan, A., Sharaf, O., Mahmoud, S., & Hegazy, R. (2020). Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy. PLoS ONE, 15(11), e0242175.
Shan, Q., Li, X., Zheng, M., Lin, X., Lu, G., Su, D., & Lu, X. (2019). Protective effects of dimethyl itaconate in mice acute cardiotoxicity induced by doxorubicin. Biochemical and Biophysical Research Communications, 517(3), 538–544.
Soleimani, R., Heytens, E., Darzynkiewicz, Z., & Oktay, K. (2011). Mechanisms of chemotherapy-induced human ovarian aging: Double strand DNA breaks and microvascular compromise. Aging (Albany NY), 3(8), 782–793.
Tabandeh, M. R., Jozaie, S., Ghotbedin, Z., & Gorani, S. (2022). Dimethyl itaconic acid improves viability and steroidogenesis and suppresses cytokine production in LPS-treated bovine ovarian granulosa cells by regulating TLR4/nfkβ, NLRP3, JNK signaling pathways. Research in Veterinary Science, 152, 89–98.
Wang, L., Wang, Y., Wang, Z., Qi, Y., Zong, B., Liu, M., ... & Ma, Y. (2018). Growth differentiation factor 11 ameliorates experimental colitis by inhibiting NLRP3 inflammasome activation. American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(6), G909–G920.
Williams, N. C., & O’Neill, L. A. (2018). A role for the Krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation. Frontiers in Immunology, 9, 141.
Wu, Y., Huang, J., Chen, H., Tao, H., He, Y., Yang, G., ... & Li, P. (2023). Tumor-derived oxidative stress triggers ovarian follicle loss in breast cancer. The American Journal of Pathology, 193(5), 608–623.
Yang, X., Chen, Y., Wang, X., Xu, G., Wang, H., Shu, X., ... & Lu, W. (2025). Ameliorative effect of itaconic acid/IRG1 against endoplasmic reticulum stress-induced necroptosis in granulosa cells via PERK-ATF4-AChE pathway in bovine. Cells, 14(6), 419.
Yildiz, S., Bildik, G., Benlioglu, C., Turan, V., Dilege, E., Ozel, M., ... & Oktay, K. (2023). Breast cancer treatment and ovarian function. Reproductive BioMedicine Online, 46(2), 313–331.
Zhan, Z., Wang, Z., Bao, Y., Liu, W., & Hong, L. (2022). OI inhibits development of ovarian cancer by blocking crosstalk between cancer cells and macrophages via HIF-1α pathway. Biochemical and Biophysical Research Communications, 606, 142–148.
Zhang, T., He, W. H., Feng, L. L., & Huang, H. G. (2017). Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regulatory Toxicology and Pharmacology, 86, 1–10.
Zhou, S., Xi, Y., Chen, Y., Zhang, Z., Wu, C., Yan, W., ... & Wang, S. (2020). Ovarian dysfunction induced by chronic whole‐body PM2.5 exposures. Small, 16(33), 2000845.