The effect of two dogs' multivalent vaccines on selective immune indices

Document Type : Research Paper

Authors

1 DVM from Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

2 Professor, Department of Pathobiology, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran

3 Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

Abstract

    Vaccination is the most important preventive measure to protect companion animals against infectious diseases. The aim of the present study was evaluation and comparison the effects of vaccination with two dogs' multivalent vaccines on selective immune indices. twenty healthy 4-month-old dogs of mixed breed and both sexes were randomly divided into two groups. The first and second group of the dogs were vaccinated with polyvalent Biocan (Group A) and Hipradog (Group B) vaccines on days 0 and 28, respectively. Blood was taken from the dogs of both groups on days 0, 28 and 35; The collected sera were assessed for lysozyme, complement, bactericidal activities, and total serum immunoglobulin. The type of vaccine and time had a significant effect on the amount of complement, but their interaction had no significant effect. Also, time had a significant effect on the amount of lysozyme, but the type of vaccine and the interaction between vaccine and time did not have a significant effect on this index. Regarding the bactericidal activity, the type of vaccine, time, and their interaction had no significant effect on the anti-Salmonella and anti-Staphylococcal activity. Vaccine type, time and the interaction between vaccine and time had a significant effect on the immunoglobulin trend changes based on the ELISA method.  The results obtained in the present study indicated that there is no significant difference between these two polyvalent vaccines in terms of antimicrobial properties; however, the Hipradog vaccine in comparison with Biocan vaccine, stimulates the production of more complement, lysozyme, and immunoglobulin, so it is recommended to use the Hipradog vaccine for dog's vaccination.

Keywords

Main Subjects

References

Barquero-Calvo, E., Martirosyan, A., Ordoñez-Rueda, D., Arce-Gorvel, V., Alfaro-Alarcón, A., Lepidi, H., . . . Moreno, E. (2013). Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus. PLoS pathogens, 9(2), e1003167.
Barrios, C., Brawand, P., Berney, M., Brandt, C., Lambert, P. H., & Siegrist, C. A. (1996). Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2‐biased pattern which persists after adult boosting. European journal of immunology, 26(7), 1489-1496.
Chan, A. C., & Carter, P. J. (2010). Therapeutic antibodies for autoimmunity and inflammation. Nature Reviews Immunology, 10(5), 301-316.
Clausse, M., Díaz, A. G., Pardo, R. P., Zylberman, V., Goldbaum, F. A., & Estein, S. M. (2017). Polymeric antigen BLSOmp31 in aluminium hydroxide induces serum bactericidal and opsonic antibodies against Brucella canis in dogs. Veterinary immunology and immunopathology, 184, 36-41.
Dall'Ara, P., Lauzi, S., Filipe, J., Caseri, R., Beccaglia, M., Desario, C., . . . Decaro, N. (2021). Discrepancy between in-clinic and haemagglutination-inhibition tests in detecting maternally-derived antibodies against canine parvovirus in puppies. Frontiers in Veterinary Science, 108.
Dall’Ara, P., Meloni, T., Rota, A., Servida, F., Filipe, J., & Veronesi, M. (2015). Immunoglobulins G and lysozyme concentrations in canine fetal fluids at term of pregnancy. Theriogenology, 83(4), 766-771.
Davis-Wurzler, G. M. (2006). Current vaccination strategies in puppies and kittens. Veterinary Clinics: Small Animal Practice, 36(3), 607-640.
Davis-Wurzler, G. M. (2014). 2013 update on current vaccination strategies in puppies and kittens. Veterinary Clinics: Small Animal Practice, 44(2), 235-263.
Day, M. J., Horzinek, M., Schultz, R., & Squires, R. (2016). WSAVA Guidelines for the vaccination of dogs and cats. The Journal of small animal practice, 57(1), E1.
Dhein, C. R., & Gorham, J. R. (1986). Host response to vaccination. Veterinary Clinics of North America: Small Animal Practice, 16(6), 1227-1245.
Dodds, W. (2021). Early Life Vaccination of Companion Animal Pets. Vaccines 2021, 9, 92. In: s Note: MDPI stays neu-tral with regard to jurisdictional clai-ms in ….
Ettinger, S. F., EC. and Cote, E. (2016). Textbook of Veterinary Internal Medicine (8th edition ed.). St. Louis, Missouri United State of America: Elsevier.
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., . . . Paganelli, R. (1993). Increased cytokine production in mononuclear cells of healthy elderly people. European journal of immunology, 23(9), 2375-2378.
Gadjeva, M. G., Rouseva, M. M., Zlatarova, A. S., Reid, K. B., Kishore, U., & Kojouharova, M. S. (2008). Interaction of human C1q with IgG and IgM: revisited. Biochemistry, 47(49), 13093-13102.
Ganz, T., & Lehrer, R. I. (1994). Defensins. Current opinion in immunology, 6(4), 584-589.
Gaskell, R., Gettinby, G., Graham, S., & Skilton, D. (2002). Veterinary Products Committee working group report on feline and canine vaccination. The Veterinary Record, 150(5), 126-134.
Greene CE, S. R. (2006). Immunoprophylaxis. In G. CE (Ed.), Infectious diseases of the dog and cat (3rd edition ed., pp. 1073–1077). St Louis Saunders Elsevier.
Hall, E., & German, A. (2010). Textbook of veterinary internal medicine. In: St. Louis (MO): Elsevier Saunders.
I, T. (2013). Vaccines and their production. In t. edition (Ed.), Veterinary immunology (pp. 258–270). St Louis Elsevier-Saunders.
Jacobs, A., Bergman, J., Theelen, R., Jaspers, R., Helps, J., Horspool, L., & Paul, G. (2007). Compatibility of a bivalent modified‐live vaccine against Bordetella bronchiseptica and cp iv, and a trivalent modified‐live vaccine against cpv, cdv and cav‐2. Veterinary record, 160(2), 41-45.
Kumar, H., Kawai, T., & Akira, S. (2009). Toll-like receptors and innate immunity. Biochemical and biophysical research communications, 388(4), 621-625.
Lie, Ø., Syed, M., & Solbu, H. (1986). Improved agar plate assays of bovine lysozyme and haemolytic complement activity. Acta Veterinaria Scandinavica, 27(1), 23-32.
McEvan, A., Fisher, E., & Salman, I. (1970). Observations on the immunoglobulin levels of neonatal buffalo calves and their relationship to diseases. J. Comp. Path, 80, 259-265.
Mila, H., Feugier, A., Grellet, A., Anne, J., Gonnier, M., Martin, M., . . . Chastant-Maillard, S. (2015). Immunoglobulin G concentration in canine colostrum: Evaluation and variability. Journal of Reproductive Immunology, 112, 24-28.
Myer, E. (2001). Vaccine-associated adverse effects. Vet. Clin. N. Am. Small Anim. Pract, 31, 493-514.
Roth, J. A. (1999). Mechanistic bases for adverse vaccine reactions and vaccine failures. Advances in veterinary medicine, 41, 681.
Schlievert, P., Johnson, W., & Galask, R. (1977). Amniotic fluid antibacterial mechanisms: newer concepts. Paper presented at the Seminars in perinatology.
Shams, F., Pourtaghi, H., & Abdolmaleki, Z. (2022). The first evaluation of the effectiveness of canine vaccination schedule by two commercial vaccines in Iran. BMC Veterinary Research, 18(1), 1-7.
Truyen, U., & Streck, A. F. (2019). Parvoviruses. Diseases of swine, 611-621.
Weiner, L. M., Surana, R., & Wang, S. (2010). Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nature Reviews Immunology, 10(5), 317-327.
Welch, M. W. (2021). Porcine parainfluenza virus 1: Evaluation of pathogenesis, strain differences, vaccine efficacy, and assay development in nursery pigs. Iowa State University,
Zanetti, M., Gennaro, R., & Romeo, D. (1995). Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS letters, 374(1), 1-5. 

Files

Share

How to cite

Statistics