Comparative study on the effect of salbutamol and formoterol on electrocardiogram, blood pressure, glucose and potassium of blood serum amounts in dogs

Document Type : Research Paper

Authors

1 DVM Graduated, Faculty of Veterinary Medicine, Tabriz Medical Scienes, Islamic Azad University, Tabriz, Iran

2 DVM Student, Faculty of Veterinary Medicine, Tabriz Medical Scienes, Islamic Azad University, Tabriz, Iran

3 Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Scienes, Islamic Azad University, Tabriz, Iran

4 Professor, Department of Pathobiology, Faculty of Veterinary Medicine, Tabriz Medical Scienes, Islamic Azad University, Tabriz, Iran

Abstract

    Today, respiratory diseases are one of the most common problems in animals and humans. One of the methods to control respiratory diseases is the use of bronchodilator drugs such as salbutamol and formoterol. The aim of the present study was to compare the effect of salbutamol and formoterol on electrocardiogram, blood pressure, potassium and glucose changes in dogs. For this purpose, fifteen male adult dogs were used. After a health check, animals were divided into three groups: control, salbutamol and formoterol. Treatment groups were inhaled daily with a single dose of one puff twice daily (morning and night) for 7 days. Finally, 4 hours after the last administration, electrocardiogram, blood pressure and arterial oxygen saturation were measured. Then, blood samples were taken from cephalic vein (5 ml) to measure blood potassium and glucose levels. Results showed that Administration of salbutamol caused a significant decrease in systolic and diastolic blood pressure, while formoterol caused a significant increase in blood pressure. Salbutamol and formoterol significantly increased heart rate. Blood potassium level as well as RR interval in electrocardiogram were significantly reduced in the groups treated with both drugs compared with the control group. The group treated with salbutamol showed a significant increase in blood glucose compared with the control group. According to the results, administration of salbutamol and formoterol reduced potassium unlike glucose. Salbutamol also was more effective than formotrol on cardiac effects and arrhythmogenic potential. Therefore, the administration of salbutamol and formoterol in cardiac or diabetic patients should be treated with caution and control.

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References

Al-Wabel, N. A., Strauch, S. M., Keene, B. W., Nakayama, T., & Hamlin, R. L. (2002). Electrocardiographic and hemodynamic effects of cisapride alone and combined with erythromycin in anesthetized dogs. Cardiovascular toxicology, 2(3), 195-207.
Alvarado, A. (2017). Dual bronchodilator therapy: A review. Clin Res Trials, 3, 1-12.
Andreas, S., Bothner, U., Trampisch, M., Haensel, M., Buhl, R., & Alter, P. (2018). Effect of long-acting β2-agonists olodaterol and formoterol on heart rate and blood pressure in chronic obstructive pulmonary disease patients. Pulmonary pharmacology & therapeutics, 52, 1-6.
Arias-Reyes, J., Matos-Martínez, M., Velásquez-Jones, L., & Dubey-Ortega, L. (1989). Correction of hyperkalemia with intravenous salbutamol in children with chronic renal insufficiency. Boletin Medico del Hospital Infantil de Mexico, 46(9), 603-606.
Bremner, P., Woodman, K., Burgess, C., Crane, J., Purdie, G., Pearce, N., & Beasley, R. (1993). A comparison of the cardiovascular and metabolic effects of formoterol, salbutamol and fenoterol. European Respiratory Journal, 6(2), 204-210.
Buonavoglia, C., & Martella, V. (2007). Canine respiratory viruses. Veterinary research, 38(2), 355-373.
Collomp, K., Candau, R., Lasne, F., Labsy, Z., Prefaut, C., & De Ceaurriz, J. (2000). Effects of short-term oral salbutamol administration on exercise endurance and metabolism. Journal of Applied Physiology, 89(2), 430-436.
Collomp, K., Candau, R., Millet, G., Mucci, P., Borrani, F., Prefaut, C., & De Ceaurriz, J. (2002). Effects of salbutamol and caffeine ingestion on exercise metabolism and performance. International journal of sports medicine, 23(08), 549-554.
Descalzi, D., Folli, C., Nicolini, G., Riccio, A., Gamalero, C., Scordamaglia, F., & Canonica, G. (2008). Anti‐proliferative and anti‐remodelling effect of beclomethasone dipropionate, formoterol and salbutamol alone or in combination in primary human bronchial fibroblasts. Allergy, 63(4), 432-437.
Faulds, D., Hollingshead, L. M., & Goa, K. L. (1991). Formoterol. Drugs, 42(1), 115-137.
Goldkorn, A., Diotto, P., Burgess, C., Weatherall, M., Holt, S., Beasley, R., & Siebers, R. (2004). The pulmonary and extra‐pulmonary effects of high‐dose formoterol in COPD: A comparison with salbutamol. Respirology, 9(1), 102-108.
Guhan, A., Cooper, S., Oborne, J., Lewis, S., Bennett, J., & Tattersfield, A. (2000). Systemic effects of formoterol and salmeterol: a dose-response comparison in healthy subjects. Thorax, 55(8), 650-656.
Jasiński, T., Owczuk, R., & Wujtewicz, M. (2018). The effect of nebulized salbutamol on atrial electrical properties in mechanically ventilated critically ill patients—a randomized, double-blind study. Anaesthesiology intensive therapy, 50(4).
Kaffash Elahi, R., mohajeri, d., nourazar, a., & Bagheri, Y. (2019). Study on Carbamazepine induced electrocardiographic, blood pressure and echocardiographic changes in the dog. Scientific Journal Management System, 13(2 (50) Summer), 177-186.
Maki, K. C., Skorodin, M. S., Jessen, J. H., & Laghi, F. (1996). Effects of oral albuterol on serum lipids and carbohydrate metabolism in healthy men. Metabolism, 45(6), 712-717.
Novodvorsky, P., Bernjak, A., Robinson, E. J., Iqbal, A., Macdonald, I. A., Jacques, R. M., Marques, J. L., Sheridan, P. J., & Heller, S. R. (2018). Salbutamol‐induced electrophysiological changes show no correlation with electrophysiological changes during hyperinsulinaemic–hypoglycaemic clamp in young people with Type 1 diabetes. Diabetic Medicine, 35(9), 1264-1272.
Nunes, C., Pereira, A. M., & Morais-Almeida, M. (2017). Asthma costs and social impact. Asthma research and practice, 3(1), 1.
Padrid, P. (2000). Canine and feline pleural disease. Veterinary Clinics: Small Animal Practice, 30(6), 1295-1308.
Parichatikanond, W., Nishimura, A., Nishida, M., & Mangmool, S. (2018). Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells. Journal of pharmacological sciences, 138 (3), 184-191.
Robertson, C., Norden, M., Fitzgerald, D., Connor, F., Van Asperen, P., Cooper, P., Francis, P., & Allen, H. (1998). Treatment of acute asthma: salbutamol via jet nebuliser vs spacer and metered dose inhaler. Journal of paediatrics and child health, 34(2), 142-146.
Rosenborg, J., Bengtsson, T., Larsson, P., Blomgren, A., Persson, G., & Lötvall, J. (2000). Relative systemic dose potency and tolerability of inhaled formoterol and salbutamol in healthy subjects and asthmatics. European journal of clinical pharmacology, 56(5), 363-370.
Sahan, M., Yılmaz, M., Gokel, Y., Erden, E., & Karakus, A. (2013). Nebulized salbutamol for asthma: Effects on serum potassium and phosphate levels at the 60 min. Revista Portuguesa de Pneumologia (English Edition), 19(5), 200-203.
Smith, A., Banks, J., Buchanan, K., Cheong, B., & Gunawardena, K. (1992). Mechanisms of abnormal glucose metabolism during the treatment of acute severe asthma. QJM: An International Journal of Medicine, 82(1), 71-80.
Vale, A. (2016). β2-Agonists. Medicine, 44(3), 146.
Varegg, M. S., Kløverød, K. M., Austnes, M. K., Siwinska, N., Slowikowska, M., Zak, A., & Niedzwiedz, A. (2019). The effect of single pretreatment with salbutamol on recovery of bronchoalveolar lavage fluid in horses with suspected or confirmed severe equine asthma. Journal of veterinary internal medicine, 33(2), 976-980.
Velasquez, L., & Muñoz, R. (1991). The treatment of hyperkalemia with salbutamol. Boletin Medico del Hospital Infantil de Mexico, 48(11), 77.779-5.

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