Histopathological study of Capparis spinossa on the healing of experimental Achilles tendon injury in rabbits

Document Type : Research Paper

Authors

1 Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Semnan, Semnan, Iran

2 DVM Graduated, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran

3 Assistant Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran

4 Assistant Professor, Department of Pathobiology, Faculty of Public Health and Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

    The critical role of tendons in body mechanics and injury and degeneration of this tissue can highly be debilitating, resulting in substantial pain, disability and costs. Capparis spinossa is one of the most common aromatic plants growing in Iran. The major objective of the study was to assess Achilles tendon healing in a rabbit model by local injection of ethanolicextract of C. spinossa. Nine adult white New Zealand male rabbits were anesthetized and partial thickness tenotomies were created on both hindlimbs. The C. spinossa extract and normal saline were respectively injected daily to the treatment and control groups for three days post-operatively. Histological analysis on days 7, 14 and 28 post-rupture demonstrated higher regenerating activity and capacity in treated groups than the control group. This was illustrated by fewer inflammatory cells, a larger number of blood vessels, further fibroblasts and increased structural organization with further longitudinally oriented collagen fibers in the treated group. In summary, these results suggest that use of C. spinossa extract can promote the healing process of damaged Achilles tendons in rabbits.

Keywords

References

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