Ivermectin Toxicosis in lamb

Document Type : Case report

Authors

Assistant Professor Department of Clinical Sciences Faculty of Veterinary medicine Ferdowsi University Of Mashhad, Mashhad, Iran

Abstract

    A 4 months male lamb with the weight of about 8 kilogram was referred to the Veterinary Teaching Hospital, University of Mashhad in winter 2012. Some hours before referring, shepherd had observed tremor, paresis and falling in the lamb. In survey of vital signs and physical examination of the animal, obvious edema of upper eyelids and muzzle, tremor, paleness of conjunctiva, absence of menace reflex, blindness, hypothermia, tachypnea, incoordination on walking, knuckling  of the fetlocks and finally sternal recumbency were revealed. After careful review of the case history and perforning some laboratory tests on whole blood, serum and cerebrospinal fluid, ivermectin toxicosis (drug overdose) was diagnosed. There is no specific antidote for this toxicosis, so supportive and symptomatic treatments were performed. The farmer slaughtered the lamb two days later. In autopsy, except for emaciation and mild ascites no macroscopic lesions were observed. Up to the authors' knowledge, this is the first report of ivermectin toxicosis in lamb in Iran and possibly in the world.

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