Metronidazole and levamisole have several clinical and biochemical side effects such as changes in the activity of serum enzymes and proteins and other profiles. There are some reports of metronidazole and levamisole effect on blood serum proteins in animals, but there is no report of these drugs on criteria in common carp. In this study, 150 common carp (100-50 g) were divided into five categories. One group served as the control (no drug) and four treatment groups: Metronidazole bath, oral metronidazole, Levamisole bath, oral levamisole was considered. After 10 days, on days 1, 7 and 14 after completion of treatment, blood samples were collected from fish and serum total protein in combination with electrophoresis was performed. According to the results, the average amount of total protein in metronidazole and levamisole treatment had no significant difference with control group . In other groups though total protein increased with the control group, but this difference was not significant. The mean Albumin, alpha-1, alpha-2, beta and gamma globulins in control group had no significant difference with other groups. The mean ALP, AST, ALT and in control group in control group has no significant difference with the other groups. Therefore it can be concluded that metronidazole in the bath treatment significantly increase AST but other factors has not been affected by these drugs. In general, this study showed that the two drugs administered in two ways, had no significant effect on the important serum enzymes and proteins. We can conclude that these two drugs can used safely in common carp, however for proving this conclusion more research must be done.