Iranian Veterinary Journal

Iranian Veterinary Journal

Evaluating the effect of oxytocin or carbetocin combined with flunixin meglumine administration and uterine lavage on the treatment of persistent-breeding induced endometritis in Dare-shuri mares

Document Type : Research Paper

Authors
Mohammad Hamedanipour 1
Naser Shams-Esfandabadi 2
Ali Kadivar 3
Ebrahim Ahmadi 4
Najmeh Davoodian 4
1 DVSc Student of Theriogenology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
2 Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran and Professor, Research Institute of Animal Embryo Technology, Shahrekord University, Shahrekord, Iran
3 Associate Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran and Associate Professor, Research Institute of Animal Embryo Technology, Shahrekord University, Shahrekord, Iran
4 Associate Professor, Research Institute of Animal Embryo Technology, Shahrekord University, Shahrekord, Iran
10.22055/ivj.2024.481335.2740
Abstract
    Persistent-breeding induced endometritis (PBIE) as the third most common disease in mares is a leading reason for infertility. Some mares do not respond effectively to traditional treatments including uterine lavage, and administration of antibiotics, anti-inflammatories, and ecbolic agents. This study explored the combined use of oxytocin and carbetocin with flunixin meglumine for treating PBIE in Dareh Shouri mares. The study involved 45 Dareh Shouri mares with PBIE. Treatment group1: mares were treated with oxytocin, flunixin meglumine, and uterine lavage with normal saline (15); treatment group2: mares were treated with carbetocin, flunixin meglumine, and uterine lavage with normal saline (15); and control, only uterine lavage with normal saline (15). Cytology samples were collected post-ovulation and pre-treatment to confirm endometritis. Pregnancy rates were assessed via ultrasonography 14 days post-ovulation. Results indicated a significantly higher pregnancy rate in the carbetocin-treated group (86%) and oxytocin-treated group (66%). A significant correlation was found between pregnancy outcomes and factors such as uterine edema, follicle size, and the interval between mating and ovulation. This study highlights the potential effectiveness of using oxytocin and carbetocin with flunixin meglumine for treating PBIE in Dareh Shouri mares, though further research is necessary for definitive conclusions.
Keywords
Persistent Breeding-Induced Endometritis
Carbetocin
Oxytocin
Flunixin meglumine
Dareh Shouri Mares

Subjects

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