دانشگاه شهید چمران اهواز نشریه دامپزشکی ایران 1735-6873 21 4 2026 01 21 Determination of phylogenetic groups, phenotypic identification of broad-spectrum beta-lactamases, and determination of antibiotic sensitivity profiles in Escherichia coli isolates in diarrheal and non-diarrheic dogs تعیین گروههای فیلوژنتیک، شناسایی فنوتیپی بتالاکتامازهای وسیع الطیف و تعیین پروفایل حساسیت آنتی بیوتیکی در جدایه های اشریشیا کلی در سگ های اسهالی و غیراسهالی 53 64 240691 10.22055/ivj.2023.398000.2584 FA فریال طعیمه پور دانش آموخته دکترای تخصصی بیماری‌های داخلی دام‌های کوچک، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران بهمن مصلی نژاد استاد گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران 0000-0001-9150-7920 داریوش غریبی استاد گروه پاتوبیولوژی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران محمد خسروی دانشیار گروه پاتوبیولوژی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران 0000-0002-2029-5067 مهدی پورمهدی بروجنی استاد گروه بهداشت مواد غذایی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران 0000-0002-9478-260X Journal Article 2023 05 18 Escherichia coli is an important member of the Enterobacteriaceae family, that can cause disease(s) in humans and a wide range of animals, including dogs and cats. The aim of the present study was to determine the phylogenetic groups and phenotypic identification of extended-spectrum beta-lactamases (ESBL) in Escherichia coli isolates obtained from diarrheal and non-diarrheic dogs and to detect the antibiotic sensitivity profile of positive ESBL isolates. The cultivation of stool samples in selected environments and confirmation of the resulting isolates were obtained by performing additional biochemical tests. Determination of the phylogenetic groups was done in the isolates by the Claremont method using primers ChuA, YjaA, TspE4.c2, and arpA; Moreover, phenotypic identification of ESBL was approved by the combined disc method and the CLSI protocol. From one hundred and fifty stool samples, 182 Escherichia coli isolates were obtained eventually. From this number, 100 isolates were selected to determine the phylogenetic groups and phenotypic identification of ESBL-producing Escherichia coli. Phylogenetic analyses showed that Escherichia coli isolates from dogs belonged to phylogeny groups A, B1, B2, D and F, with prevalence rates of 39%, 42%, 4%, 9% and 6%, respectively. Also, the frequency of phylogenetic groups in diarrheal dogs was (42.3%) in group A, (38.5%) in B1, (9.6%) in D, (5.8%) in F, and (3.9%) in B2. In addition, in healthy dogs, the phylogeny groups were in (43.07%) in group B1, (39.26%) in A, (7.7%) in D, (6.2%) in F and (3.96%) in B2. Out of 100 Escherichia coli isolates, 31 isolates (31%) were phenotypically beta-lactamase ESBLs producers. Twelve isolates (38.7%) were related to diarrhea samples and 19 isolates (61.3%) were related to healthy dogs. The high prevalence of Escherichia coli isolates producing ESBL enzymes in Ahvaz district increases the risk of spread and transmission of ESBL-producing strains in the pet population and their transmission to the human population. <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> باکتری اشریشیا کلی، یکی از اعضای مهم خانواده انتروباکتریاسه است که میتواند موجب بیماری در انسان و طیف وسیعی از حیوانات از جمله سگ و گربه شود. هدف از انجام مطالعه حاضر، تعیین گروه های فیلوژنتیکی،<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> شناسایی فنوتیپی بتالاکتامازهای وسیع الطیف (<span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">ESBL<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">) در جدایه های اشریشیا کلی حاصل از سگ های اسهالی و غیراسهالی و تعیین پروفایل حساسیت آنتی بیوتیکی در جدایه های <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">ESBL<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> مثبت <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">بود. کشت نمونه های مدفوع در محیط های انتخابی و تأیید جدایه های حاصل با انجام آزمایش های بیوشیمیایی تکمیلی حاصل شد. تعیین گروه های فیلوژنتیکی در جدایه ها، به روش کلرمونت با استفاده از پرایمرهای ChuA<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">، YjaA<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">، TspE4.c2<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">و<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> arpA<span style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">و <span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">شناسایی فنوتیپی <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">ESBL<span style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">به روش دیسک ترکیبی و مطابق با پروتوکل CLSI<span style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> صورت گرفت<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">.<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> از 150 نمونه مدفوع، <span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">در مجموع <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">182 جدایه اشریشیا کلی به دست آمد. از این تعداد، 100 جدایه،<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> جهت تعیین <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">گروه های فیلوژنتیکی و شناسایی فنوتیپی اشریشیا کلی تولید کننده ESBL<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> انتخاب شدند. آنالیزهای فیلوژنتیکی نشان داد که جدایه های اشریشیا کلی از سگها، متعلق به گروه های فیلوژنی A<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">، B1<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">،<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">B2<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">، <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">D<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> و <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">F<span style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> و به ترتیب با میزان شیوع <span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">39<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">، 42، 4، 9<span dir="LTR" lang="AR-SA" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-no-proof: yes;"> <span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">و 6 درصد<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> بودند. <span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">همچنین فراوانی گروه های فیلوژنی در سگ های اسهالی در گروه <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">A<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (3/42 درصد)، <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">B1<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (5/38 درصد)، <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">D<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (6/9 درصد)،<span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">F <span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (8/5 درصد) و <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">B2<span style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> <span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">(9/3 درصد) به دست آمد. به علاوه در سگ های سالم نیز فراوانی گروههای فیلوژنی در گروه <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">B1<span style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (07/43 درصد)، <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">A<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (26/39 درصد)، <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">D<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (7/7 درصد)، <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">F<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (2/6 درصد) و <span dir="LTR" style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: 'B Yagut'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;">B2<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> (96/3 درصد) بودند. <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt;">از ۱۰۰ جدایه‌ی اشریشیا کلی، ۳۱ جدایه (۳۱ درصد) از لحاظ فنوتیپی<span lang="FA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA;">، <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt;">تولیدکننده آنزیم‌های بتالاکتاماز ESBLs بودند. دوازده جدایه (۷/۳۸ درصد) مربوط به نمونه‌های اسهالی و ۱۹ جدایه (۳/۶۱ درصد) مربوط به سگ های سالم بودند. شیوع بالای جدایه‌های اشریشیا کلی تولید کننده آنزیم‌های ESBLs<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> در منطقه اهواز، افزایش احتمال خطر گسترش و انتقال سویه‌های تولیدکننده ESBLs<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;"> در جمعیت حیوانات خانگی و انتقال آن به جمعیت انسانی<span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-bidi-language: FA; mso-no-proof: yes;"> <span lang="AR-SA" style="font-size: 10.0pt; font-family: 'B Yagut'; mso-ascii-font-family: 'Times New Roman'; mso-fareast-font-family: Calibri; mso-hansi-font-family: 'Times New Roman'; letter-spacing: -.1pt; mso-no-proof: yes;">را به دنبال دارد.

https://www.ivj.ir/article_240691_61ba8c00892a6923b9a707187e67b8fa.pdf