The effect of experimental hypothyroidism on some blood biochemical parameters of common carp

Document Type : Research Paper

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Abstract

    Due to the effects of some pollutants on the thyroid gland function and to assess the effects of hypothyroidism on some blood biochemical parameters of common carps, this study was conducted. Fishes were divided into four groups of 30 each. The groups were treated by zero (control group), 3, 9 and 27 mg/L of propylthiouracil in water for one month. After 1 month, blood was taken from 15 fishes from each group and their weight, serum thyroid hormones, triglycerides, total cholesterol, HDL-c, LDL-c, glucose and serum urea urea were measured. For the reminder, the drug application was discontinued and the other halves of the fish were examined one month later, in the similar manner to the previous stage. In stage 1 (after one month) in comparison between different groups, thyroid hormones did not show significant difference (p>0.05), but in the second stage, T4 level was lower in the treatment groups in comparison with the control (p<0.05). T3 level in 3 and 9 mg/l groups were higher than 27 mg/L group and the control (p<0.05). The triglycerides level was higher in 3 and 9 mg/L groups compared to control group (p<0.05). HDL-c in the second stage in 3 mg/L group was higher than the control group and 27mg/L group (p<0.05). Glucose in the second stage was significantly lower in 9 mg/l group in comparaison with the control group (p<0.05). Urea also increased in the treated groups in comparison with the control (p<0.05). Accordingly, it is concluded that thyroid hormones had responded to the treatment with delay and their changes have affected the studied variables dependently.

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