Comparative effect of isosmotic and hyperosmotic dextrose solutions on plasma protein, albumin, glucose, triglyceride and total cholesterol of newborn calves

Charoosaei, A; Fatemi Tabatabaei, R; Rassoli, A; Noori, M; Moravedji, M

Comparative effect of isosmotic and hyperosmotic dextrose solutions on plasma protein, albumin, glucose, triglyceride and total cholesterol of newborn calves

Document Type : Research Paper

Authors

Abstract

Isosmotic and hyperosmotic solutions of dextrose have many uses in veterinary medicine. Following application of these solutions, fluid displacement and changes in plasma levels of glucose, lipids, total protein and albumin may take place. This study was carried out to evaluate the effect of this kind of solutions on homeostasis of plasma glucose, lipid, total protein and albumin. One ml/kg of 5 and 50% dextrose solutions were administered by rapid and intermittent IV injection to six 8-10 day old calves. Repeated blood sampling was obtained during next 12 hour to measure protein, albumin, triglyceride (TG) and total cholesterol (TC). According to the data 5% and 50% dextrose solutions led to a durable mild, and a short term, high-increase in plasma glucose, respectively (P<0.05). These solutions mildly and transiently decreased plasma protein and albumin levels (P<0.05). TG increased until 120 and 180 min after treatment with 5 and 50 percent dextrose solutions. Total cholesterol increased significantly following injection of 5% dextrose solution. These differences between 5% and 50% dextrose solutions may be related to different insulin levels released, following different plasma glucose levels. Thus we suggest paying attention to the dextrose solutions administration during the interpretation, of the above parameters.

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