Evaluate the effect of caffeine consumption during pregnancy on lens development of the neonate rat

Document Type : Research Paper

Authors

1 عضو هیات علمی

2 Veterinary Medicine, Tehran University

3 Faculty of Veterinary Medicine, Tehran University

Abstract

    Consumption of harmful edibles during pregnancy may cause fetal abnormalities in development of various systems, including the visual system. Awareness and realizing of harmful factors can lead to a decrease in birth injury. Considering the importance of the visual system development and due to caffeine is frequently used during pregnancy, this study investigated the effect of caffeine on neonatal rat during the formation of embryonic visual system.  In this experimental study 24 Wistar pregnant rats were divided into three groups (two experimental groups and one control group). Experimental groups received 50 and 100 mg/kg daily 8-21 GD (gestational days) intraperitoneal of caffeine, respectively and the control group received normal saline. Offsprings were collected and eyes were removed at day 21. Offsprings were studied for macroscopic abnormalities, also histological and histomorphometric evaluation of lens were performed. The results showed that caffeine consumption during pregnancy can cause delay and defects in eye development including the lens and also the maximum and the most important histomorphometric changes was occurred at the dose of 100 mg/kg. Moreover, data showed that significant reduction of offsprings weight in experimental groups and reduction of crown rump length in experimental groups in comparison with control group. Accordance to microscopy and histopathology evidence, caution is recommend caffeine intake by pregnant women.

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